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American Society of Microbiology ABMM Exam Syllabus Topics:

American Society of Microbiology ABMM Sample Questions:

Question 1

A traveler returning from a tropical region presents with fever, chills, and jaundice. Peripheral blood smear reveals the presence of ring-shaped parasites within erythrocytes. Further laboratory testing shows a positive result for Plasmodium falciparum histidine-rich protein 2 (HRP2). The MOST appropriate treatment for this patient is:

A. Amphotericin B
B. Metronidazole
C. Primaquine and a blood schizonticide (e.g., artemisinin-based combination therapy)
D. Mebendazole

Question 2

A patient develops a vesicular rash on their hands and feet, accompanied by fever and oral ulcers. The MOST likely causative agent is:

A. Coxsackievirus A
B. Herpes simplex virus
C. Measles virus
D. Varicella-zoster virus

Question 3

A patient develops severe, watery diarrhea shortly after starting a course of clindamycin. Stool testing using a cytotoxicity assay is positive. This result is most consistent with infection by which organism?

A. Campylobacter jejuni
B. Giardia lamblia
C. Norovirus
D. Clostridioides difficile

Question 4

Transmissible spongiform encephalopathies (TSEs), such as Creutzfeldt-Jakob disease (CJD) in humans and Bovine Spongiform Encephalopathy (BSE) in cattle, are caused by infectious agents composed primarily of:

A. Viroids (small, circular RNA molecules)
B. Slow-growing bacteria lacking a cell wall
C. Defective viral particles requiring a helper virus
D. Aberrantly folded host-encoded prion proteins (PrP<sup>Sc</sup>)

Question 5

During a community outbreak of influenza, a public health laboratory performs rapid antigen testing on nasopharyngeal swabs. A test for influenza A is positive, but the influenza B test is negative. Subsequently, RT-PCR is performed on the same sample, and it is negative for both influenza A and B viral RNA. The MOST likely explanation for this discordant result is:

A. The patient was infected with a novel influenza strain not detected by either assay.
B. The rapid antigen test yielded a false positive result, and the RT-PCR was a true negative.
C. The rapid antigen test has low sensitivity, resulting in a false positive.
D. The RT-PCR assay has a high limit of detection, missing a low viral load.

Solutions: